Spindle Orientation: Timing Is Everything
نویسنده
چکیده
In this issue of Neuron, Xie et al. (2013) identified protein phosphatase 4c (PP4c) as a new component in the regulation of spindle orientation during mammalian neurogenesis. Importantly, their findings uncovered a novel and critical temporal aspect of the regulation of spindle orientation during neurogenesis.
منابع مشابه
Multiple Wnt signaling pathways converge to orient the mitotic spindle in early C. elegans embryos.
How cells integrate the input of multiple polarizing signals during division is poorly understood. We demonstrate that two distinct Caenorhabditis elegans Wnt pathways contribute to the polarization of the ABar blastomere by differentially regulating its duplicated centrosomes. Contact with the C blastomere orients the ABar spindle through a nontranscriptional Wnt spindle alignment pathway, whi...
متن کاملRegulation of mitotic progression by factors that influence spindle position and stability in fission yeast
It has previously been proposed that in fission yeast mitotic spindle position is monitored by a checkpoint that controls the timing of anaphase onset. This checkpoint is activated by treatment of cells with Latrunculin A (Lat A), an inhibitor of actin polymerisation. It was previously thought that Lat A imposes an anaphase delay by preventing interaction of astral microtubules with the cortica...
متن کاملEffect of Cell Shape and Dimensionality on Spindle Orientation and Mitotic Timing
The formation and orientation of the mitotic spindle is a critical feature of mitosis. The morphology of the cell and the spatial distribution and composition of the cells' adhesive microenvironment all contribute to dictate the position of the spindle. However, the impact of the dimensionality of the cells' microenvironment has rarely been studied. In this study we present the use of a microwe...
متن کاملPolo-like kinase Cdc5 regulates Spc72 recruitment to spindle pole body in the methylotrophic yeast Ogataea polymorpha
Cytoplasmic microtubules (cMT) control mitotic spindle positioning in many organisms, and are therefore pivotal for successful cell division. Despite its importance, the temporal control of cMT formation remains poorly understood. Here we show that unlike the best-studied yeast Saccharomyces cerevisiae, position of pre-anaphase nucleus is not strongly biased toward bud neck in Ogataea polymorph...
متن کاملWhen the Swiss clock goes wrong
A Swiss clock and entry into mitosis have something in common: both must be very precise. When the Swiss clock goes wrong, the consequence is the loss of reputation. When entry into mitosis goes wrong, cells may divide in an aberrant way. More generally, cell division events are tightly regulated at the temporal and spatial levels. We have recently shown that in C. elegans, misregulation of the...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Neuron
دوره 79 شماره
صفحات -
تاریخ انتشار 2013